Spatial memory testing decreases hippocampal amyloid precursor protein in young, but not aged, female rats

Heather A. Bimonte; Ann Charlotte E. Granholm; Hyemyung Seo; Ole Isacson

doi:10.1016/S0304-3940(02)00442-1

Spatial memory testing decreases hippocampal amyloid precursor protein in young, but not aged, female rats

Heather A. Bimonte, Ann Charlotte E. Granholm, Hyemyung Seo, Ole Isacson

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Using young and aged rats, we investigated relationships between amyloid precursor protein (APP) and working or reference memory, as well as assessed whether cognitive testing altered APP levels. In young rats, higher APP levels were related to more working memory errors as a linear function. Aged rats exhibited a curvilinear relationship between APP and working memory, with moderate APP levels associated with better relative performance. A comparison of rats that received cognitive testing with those that did not showed that testing decreased APP levels in young, but not aged, rats. Collectively, the data suggest that young and aged rats exhibit different relationships between APP and working memory, and that aged rats do not maintain the capacity to decrease APP in response to cognitive testing.

Original language	English (US)
Pages (from-to)	50-54
Number of pages	5
Journal	Neuroscience Letters
Volume	328
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3940(02)00442-1
State	Published - Aug 2 2002
Externally published	Yes

Keywords

Aging
Amyloid precursor protein
Hippocampus
Learning
Radial arm
Working memory

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/S0304-3940(02)00442-1

Cite this

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title = "Spatial memory testing decreases hippocampal amyloid precursor protein in young, but not aged, female rats",

abstract = "Using young and aged rats, we investigated relationships between amyloid precursor protein (APP) and working or reference memory, as well as assessed whether cognitive testing altered APP levels. In young rats, higher APP levels were related to more working memory errors as a linear function. Aged rats exhibited a curvilinear relationship between APP and working memory, with moderate APP levels associated with better relative performance. A comparison of rats that received cognitive testing with those that did not showed that testing decreased APP levels in young, but not aged, rats. Collectively, the data suggest that young and aged rats exhibit different relationships between APP and working memory, and that aged rats do not maintain the capacity to decrease APP in response to cognitive testing.",

keywords = "Aging, Amyloid precursor protein, Hippocampus, Learning, Radial arm, Working memory",

author = "Bimonte, {Heather A.} and Granholm, {Ann Charlotte E.} and Hyemyung Seo and Ole Isacson",

note = "Funding Information: This work was funded by grants from the National Institute on Aging: AG04418; AG12122; and AG10755. ",

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T1 - Spatial memory testing decreases hippocampal amyloid precursor protein in young, but not aged, female rats

AU - Bimonte, Heather A.

AU - Granholm, Ann Charlotte E.

AU - Seo, Hyemyung

AU - Isacson, Ole

N1 - Funding Information: This work was funded by grants from the National Institute on Aging: AG04418; AG12122; and AG10755.

PY - 2002/8/2

Y1 - 2002/8/2

N2 - Using young and aged rats, we investigated relationships between amyloid precursor protein (APP) and working or reference memory, as well as assessed whether cognitive testing altered APP levels. In young rats, higher APP levels were related to more working memory errors as a linear function. Aged rats exhibited a curvilinear relationship between APP and working memory, with moderate APP levels associated with better relative performance. A comparison of rats that received cognitive testing with those that did not showed that testing decreased APP levels in young, but not aged, rats. Collectively, the data suggest that young and aged rats exhibit different relationships between APP and working memory, and that aged rats do not maintain the capacity to decrease APP in response to cognitive testing.

AB - Using young and aged rats, we investigated relationships between amyloid precursor protein (APP) and working or reference memory, as well as assessed whether cognitive testing altered APP levels. In young rats, higher APP levels were related to more working memory errors as a linear function. Aged rats exhibited a curvilinear relationship between APP and working memory, with moderate APP levels associated with better relative performance. A comparison of rats that received cognitive testing with those that did not showed that testing decreased APP levels in young, but not aged, rats. Collectively, the data suggest that young and aged rats exhibit different relationships between APP and working memory, and that aged rats do not maintain the capacity to decrease APP in response to cognitive testing.

KW - Aging

KW - Amyloid precursor protein

KW - Hippocampus

KW - Learning

KW - Radial arm

KW - Working memory

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Spatial memory testing decreases hippocampal amyloid precursor protein in young, but not aged, female rats

Abstract

Keywords

ASJC Scopus subject areas

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