@article{3fe9b28810264bd3a4db3a00c393e5fe,
title = "SNP-based genetic characterization of the Tulane National Primate Research Center's conventional and specific pathogen-free rhesus macaque (Macaca mulatta) populations",
abstract = "Background: The rhesus macaque is an important biomedical model organism, and the Tulane National Primate Research Center (TNPRC) has one of the largest rhesus macaque breeding colonies in the United States. Methods: SNP profiles from 3266 rhesus macaques were used to examine the TNPRC colony genetic composition over time and across conventional or SPF animals of Chinese and Indian ancestry. Results: Chinese origin animals were the least genetically diverse and the most inbred; however, since their derivation from their conventional forebearers, neither the Chinese nor the Indian SPF animals exhibit any significant loss of genetic diversity or differentiation. Conclusions: The TNPRC colony managers have successfully minimized loss in genetic variation across generations. Although founder effects and bottlenecks among the Indian animals have been successfully curtailed, the Chinese subpopulation still show some influences from these events.",
keywords = "genetic composition, genetic management, genetic structure, population genetics, single nucleotide polymorphisms",
author = "Sreetharan Kanthaswamy and Jillian Ng and Oldt, {Robert F.} and Kathrine Phillippi-Falkenstein and Kubisch, {H. Michael}",
note = "Funding Information: Funding information This study was supported by the NIH grants P51 OD011104, 4U24OD011109, and 4U42OD010568, to the Tulane National Primate Research Center and NIH grant P51 OD011107 to the California National Primate Research Center. The authors wish to express their substantial thanks to the other members of the Genetics and Genomics Working Group of the National Nonhuman Primate Research Consortium for their comments and suggestions during the development of this study. The genetic test reported here developed out of discussions within the Genetics and Genomics Working Group, and the authors wish to thank all who contributed to that process. Funding for the development of this SNP assay was provided by the Office of Research Infrastructure Programs in the Office of the Director, NIH. This work began when that organization was part of the Comparative Medicine program of the National Center for Research Resources, NIH. We wish to express our sincere thanks to Dr. John Harding for his consistent and valuable support of the Genetics and Genomics Working Group and all its activities. Funding Information: The authors wish to express their substantial thanks to the other members of the Genetics and Genomics Working Group of the National Nonhuman Primate Research Consortium for their comments and suggestions during the development of this study. The genetic test reported here developed out of discussions within the Genetics and Genomics Working Group, and the authors wish to thank all who contributed to that process. Funding for the development of this SNP assay was provided by the Office of Research Infrastructure Programs in the Office of the Director, NIH. This work began when that organization was part of the Comparative Medicine program of the National Center for Research Resources, NIH. We wish to express our sincere thanks to Dr. John Harding for his consistent and valuable support of the Genetics and Genomics Working Group and all its activities. Funding Information: This study was supported by the NIH grants P51 OD011104, 4U24OD011109, and 4U42OD010568, to the Tulane National Primate Research Center and NIH grant P51 OD011107 to the California National Primate Research Center. Publisher Copyright: {\textcopyright} 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd",
year = "2018",
month = feb,
doi = "10.1111/jmp.12284",
language = "English (US)",
volume = "47",
pages = "29--34",
journal = "Journal of Medical Primatology",
issn = "0047-2565",
publisher = "Blackwell Munksgaard",
number = "1",
}