Small HIV-1-Tat peptides inhibit HIV replication in cultured T-cells

Marianne Löhr, Karen V. Kibler, Ian Zachary, Kuan Teh Jeang, David L. Selwood

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Full-length soluble HIV-1 Tat protein has been shown to bind the CXCR4 receptor. Occupancy of CXCR4 by Tat inhibits infection of cells by T-tropic HIV-1. To understand if fragments of the Tat protein may have similar anti-HIV activity, we synthesized Tat peptides and tested their activity in tissue culture. Here, we report a sequence-specific contribution of Tat residues 31-35 to anti-HIV-1 activity.

Original languageEnglish (US)
Pages (from-to)609-613
Number of pages5
JournalBiochemical and Biophysical Research Communications
Issue number2
StatePublished - Jan 10 2003
Externally publishedYes


  • Chemokine receptor
  • Cyclic peptide
  • Human immunodeficiency virus
  • Tat protein

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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