Skelemin association with αiIbβ3 integrin: A structural model

Vitaliy Gorbatyuk, Khiem Nguyen, Nataly Podolnikova, Lalit Deshmukh, Xiaochen Lin, Tatiana Ugarova, Olga Vinogradova

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Over the last two decades, our knowledge concerning intracellular events that regulate integrins affinity to their soluble ligands has significantly improved. However, the mechanism of adhesion-induced integrin clustering and development of focal complexes, which could further mature to form focal adhesions, still remains under-investigated. Here we present a structural model of tandem IgC2 domains of skelemin in complex with the cytoplasmic tails of integrin αIIbβ3. The model of tertiary assembly is generated based upon NMR data and illuminates a potential link between the essential cell adhesion receptors and myosin filaments. This connection may serve as a basis for generating the mechanical forces necessary for cell migration and remodeling.

Original languageEnglish (US)
Pages (from-to)6766-6775
Number of pages10
Issue number43
StatePublished - Nov 4 2014

ASJC Scopus subject areas

  • Biochemistry


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