Site-specific (targeted) drug delivery in cancer therapy

George Poste, Richard Kirsh

Research output: Contribution to journalArticlepeer-review

143 Scopus citations


The current status of efforts to target cytotoxic agents to tumor cells using antitumor antibodies and particulate drug carriers such as liposomes and microspheres is reviewed. Emphasis is given to the role of anatomic and physiologic factors in determining the disposition, fate, and therapeutic efficacy of targeted drug delivery systems and to the importance of tumor cell heterogeneity as a major obstacle to effective cancer therapy.

Original languageEnglish (US)
Pages (from-to)869-878
Number of pages10
Issue number10
StatePublished - Dec 1983
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology


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