Single molecule diffraction

J. C.H. Spence, R. B. Doak

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


The use of hydrated molecules within helium droplets was proposed for the structure analysis of small proteins. The use of a continuous electron beam and deep ultracold droplet source was suggested, and molecules were aligned with simple plane-polarized laser. The laser system used a quarter-wave plate to generate elliptically polarized light, which fixed the orientation of passing molecules. The use of hydrated molecules within helium droplets resulted in reduced radiation damage, and improved the degree of alignment.

Original languageEnglish (US)
Article number198102
Pages (from-to)198102-1-198102-4
JournalPhysical Review Letters
Issue number19
StatePublished - May 14 2004

ASJC Scopus subject areas

  • General Physics and Astronomy


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