@inproceedings{78f8c5d93f01417b88e1c72a6d07fd2d,
title = "Simultaneous detection of multiple contrast agents with photoacoustic spectroscopy",
abstract = "Early detection of cancer is important for survival, and multiple targeted contrast agents can be used for advanced cellular profiling. Photoacoustic (PA) imaging is effective at imaging optically-absorbing contrast agents. In this study, we present simulated and experimental results using spectral decomposition to separate the PA absorption spectrum into components from individual contrast agents. The original co-localized concentration of each agent is then simultaneously reconstructed. Monte Carlo simulations were performed to estimate wavelength-dependent fluences in the sample. In phantom experiments, the concentration of two contrast agents (gold nanorods with different absorption spectra) and a background absorbing dye (India Ink) were reconstructed. Finally, we implemented our algorithm in a mouse after injections of gold nanorods with absorption peaks of 750 and 810 nm. The concentration of each nanoparticle was identified from the endogenous background signal with a signal-to-noise ratio of greater than 25 dB.",
keywords = "breast cancer, gold nanorods, molecular imaging, optoacoustic, spectral decomposition algorithm",
author = "Bauer, {Daniel R.} and Montilla, {Leonardo G.} and Mir Salek and Nathan Allen and Kaushal Rege and Witte, {Russell S.}",
year = "2012",
month = dec,
day = "1",
doi = "10.1109/ULTSYM.2012.0355",
language = "English (US)",
isbn = "9781467345613",
series = "IEEE International Ultrasonics Symposium, IUS",
pages = "1421--1424",
booktitle = "2012 IEEE International Ultrasonics Symposium, IUS 2012",
note = "2012 IEEE International Ultrasonics Symposium, IUS 2012 ; Conference date: 07-10-2012 Through 10-10-2012",
}