Simulation of diabetic retinopathy neovascularization in color digital fundus images

Xinyu Xu, Baoxin Li, Jose F. Florez, Helen K. Li

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations


Diabetic retinopathy (DR) has been identified as a leading cause of blindness. One type of lesion, neovascularization (NV), indicates that the disease has entered a vision-threatening phase. Early detection of NV is thus clinically significant. Efforts have been devoted to use computer-aided analyses of digital retina images to detect DR. However, developing reliable NV detection algorithms requires large numbers of digital retinal images to test and refine approaches. Computer simulation of NV offers the potential of developing lesion detection algorithms without the need for large image databases of real pathology. In this paper, we propose a systematic approach to simulating NV. Specifically, we propose two algorithms based on fractal models to simulate the main structure of NV and an adaptive color generation method to assign photorealistic pixel values to the structure. Moreover, we develop an interactive system that provides instant visual feedback to support NV simulation guided by an ophthalmologist. This enables us to combine the low level algorithms with high-level human feedback to simulate realistic lesions. Experiments suggest that our method is able to produce simulated NVs that are indistinguishable from real lesions.

Original languageEnglish (US)
Title of host publicationAdvances in Visual Computing - Second International Symposium, ISVC 2006, Proceedings
PublisherSpringer Verlag
Number of pages13
ISBN (Print)3540486283, 9783540486282
StatePublished - Jan 1 2006
Event2nd International Symposium on Visual Computing, ISVC 2006 - Lake Tahoe, NV, United States
Duration: Nov 6 2006Nov 8 2006

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume4291 LNCS - I
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349


Other2nd International Symposium on Visual Computing, ISVC 2006
Country/TerritoryUnited States
CityLake Tahoe, NV

ASJC Scopus subject areas

  • Theoretical Computer Science
  • General Computer Science


Dive into the research topics of 'Simulation of diabetic retinopathy neovascularization in color digital fundus images'. Together they form a unique fingerprint.

Cite this