Side-viewing photoacoustic waveguide endoscopy

Christopher Miranda; Ethan Marschall; Blake Browning; Barbara S. Smith

doi:10.1016/j.pacs.2020.100167

Side-viewing photoacoustic waveguide endoscopy

Christopher Miranda, Ethan Marschall, Blake Browning, Barbara S. Smith

Engineering, Ira A. Fulton Schools of (IAFSE)

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Side-viewing hollow optical waveguides allow for minimally invasive endoscopy by concentrically guiding light and sound for photoacoustic generation and detection. Here, we characterize the side-viewing photoacoustic waveguide (PWG) endoscope by scanning 7.2 μm diameter carbon fiber threads within phantom tissues and animal tissues. Photoacoustic signals are carried along the 5.5 and 10.0 cm length of the PWG with minimal attenuation. Thus, this technology enables 360°, deep-tissue photoacoustic imaging. Photoacoustic signals were identified up to 8.0 mm from the PWG imaging window in an optically clear medium. The outer diameter of this device is measured as just over 1.0 mm, with the potential to be further miniaturized due to its unique design. The PWG is an ideal candidate for a myriad of pre-clinical and clinical applications where typical photoacoustic endoscopy systems are impractical, due to their size. Presented here, is the first side-viewing photoacoustic waveguide endoscope.

Original language	English (US)
Article number	100167
Journal	Photoacoustics
Volume	19
DOIs	https://doi.org/10.1016/j.pacs.2020.100167
State	Published - Sep 2020

Keywords

Photoacoustic endoscopy waveguide

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics
Radiology Nuclear Medicine and imaging

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10.1016/j.pacs.2020.100167

Cite this

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title = "Side-viewing photoacoustic waveguide endoscopy",

abstract = "Side-viewing hollow optical waveguides allow for minimally invasive endoscopy by concentrically guiding light and sound for photoacoustic generation and detection. Here, we characterize the side-viewing photoacoustic waveguide (PWG) endoscope by scanning 7.2 μm diameter carbon fiber threads within phantom tissues and animal tissues. Photoacoustic signals are carried along the 5.5 and 10.0 cm length of the PWG with minimal attenuation. Thus, this technology enables 360°, deep-tissue photoacoustic imaging. Photoacoustic signals were identified up to 8.0 mm from the PWG imaging window in an optically clear medium. The outer diameter of this device is measured as just over 1.0 mm, with the potential to be further miniaturized due to its unique design. The PWG is an ideal candidate for a myriad of pre-clinical and clinical applications where typical photoacoustic endoscopy systems are impractical, due to their size. Presented here, is the first side-viewing photoacoustic waveguide endoscope.",

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author = "Christopher Miranda and Ethan Marschall and Blake Browning and Smith, {Barbara S.}",

note = "Funding Information: Barbara S. Smith joined Arizona State University's School of Biological and Health Systems Engineering as an Assistant Professor in January 2015. The Smith Laboratory focuses on engineering solutions to better diagnose problems associated with women{\textquoteright}s health and mental illness. Ongoing research in her lab aims to develop novel imaging technologies and utilize multiomic analysis to forge entirely new paths towards early stage detection and diagnostic monitoring. Her overarching goal is to translate research and clinical technologies created in the lab for improved patient outcomes. Recent work in the Smith Lab, on photoacoustic waveguides, has led to the publication of a featured article in Applied Physics Letters. Smith has received the NSF CAREER Award, Centennial Professorship Award, New Innovator Award from the Arizona Biomedical Research Consortion, and the NSF I-Corps Award for translational research, among others. Publisher Copyright: {\textcopyright} 2020",

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doi = "10.1016/j.pacs.2020.100167",

language = "English (US)",

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Side-viewing photoacoustic waveguide endoscopy

Abstract

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ASJC Scopus subject areas

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