Sick of sitting

James A. Levine

Research output: Contribution to journalReview articlepeer-review

42 Scopus citations


Sitting too much kills. Epidemiological, physiological and molecular data suggest that sedentary lifestyle can explain, in part, how modernity is associated with obesity, more than 30 chronic diseases and conditions and high healthcare costs. Excessive sitting―sitting disease―is not innate to the human condition. People were designed to be bipedal and, before the industrial revolution, people moved substantially more throughout the day than they do presently. It is encouraging that solutions exist to reverse sitting disease. Work environments, schools, communities and cities can be re-imagined and re-invented as walking spaces, and people thereby offered more active, happier, healthier and more productive lives.

Original languageEnglish (US)
Pages (from-to)1751-1758
Number of pages8
Issue number8
StatePublished - Aug 23 2015


  • Chronic disease
  • Diabetes
  • Non-exercise activity thermogenesis
  • Obesity
  • Physical activity
  • Review

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism


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