TY - GEN
T1 - Shape analysis and classification of lgl-type and wild-type neurons
AU - Mounsef, Jinane
AU - Karam, Lina
AU - Estes, Patricia
AU - Zarnescu, Daniela
PY - 2010
Y1 - 2010
N2 - Among the tumor suppressors identified in Drosophila, lgl is one of a few whose proliferative phenotype is shown to be secondary to a loss of cell polarity. Studies of lgl mutant phenotypes are likely to contribute to our understanding of both tumorigenesis as well as neural development mechanisms. However, alterations of neuronal development as a result of key protein mutations are not easy to describe without quantifiable parameters. This work presents a fully automated imaging technique that involves skeletonization and histogram-based features such as kurtosis to find and quantify discriminative morphological phenotypes that can be used to automatically distinguish normal wild-type neurons from lgl mutant neurons.
AB - Among the tumor suppressors identified in Drosophila, lgl is one of a few whose proliferative phenotype is shown to be secondary to a loss of cell polarity. Studies of lgl mutant phenotypes are likely to contribute to our understanding of both tumorigenesis as well as neural development mechanisms. However, alterations of neuronal development as a result of key protein mutations are not easy to describe without quantifiable parameters. This work presents a fully automated imaging technique that involves skeletonization and histogram-based features such as kurtosis to find and quantify discriminative morphological phenotypes that can be used to automatically distinguish normal wild-type neurons from lgl mutant neurons.
KW - Feature descriptor
KW - Global kurtosis-based training
KW - Lethal giant larvae (lgl) mutant phenotype
KW - Morphological skeletonization
KW - Multi-level kurtosis-based training
KW - No-reference-based classification
KW - Reduced-reference-based classification
KW - Reference-based classification
KW - Tree graph structure
UR - http://www.scopus.com/inward/record.url?scp=77958069263&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77958069263&partnerID=8YFLogxK
U2 - 10.1145/1854776.1854830
DO - 10.1145/1854776.1854830
M3 - Conference contribution
AN - SCOPUS:77958069263
SN - 9781450304382
T3 - 2010 ACM International Conference on Bioinformatics and Computational Biology, ACM-BCB 2010
SP - 362
EP - 365
BT - 2010 ACM International Conference on Bioinformatics and Computational Biology, ACM-BCB 2010
T2 - 2010 ACM International Conference on Bioinformatics and Computational Biology, ACM-BCB 2010
Y2 - 2 August 2010 through 4 August 2010
ER -