Self-assembly of DNA rings from scaffold-free DNA tiles

Yang Yang, Zhao Zhao, Fei Zhang, Jeanette Nangreave, Yan Liu, Hao Yan

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


We report a scaffold-free approach in which four- and six-helix DNA bundle units, assembled from a small number of single stranded DNA oligonucleotides precisely arranged in networks of contiguous and semicrossover strands, are connected into DNA nano rings. Nearly uniform structures with well-defined diameters of 53 ± 7, 81 ± 9, 85 ± 8, and 166 ± 13 nm were achieved by introducing uniform, in-plane curvature to the repeating units. We demonstrate that precise higher order assemblies can be achieved by fine tuning the particular features of the individual building blocks.

Original languageEnglish (US)
Pages (from-to)1862-1866
Number of pages5
JournalNano Letters
Issue number4
StatePublished - Apr 10 2013


  • DNA nanotechnology
  • DNA rings
  • DNA self-assembly
  • scaffold free

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering


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