TY - JOUR
T1 - Self-assembly for the synthesis of functional biomaterials
AU - Stephanopoulos, Nicholas
AU - Ortony, Julia H.
AU - Stupp, Samuel I.
N1 - Funding Information:
Research in the authors’ laboratory described in this paper was supported by grants from the National Institutes of Health under Award #’s (5R01DE015920-07; 5R01EB003806-07), the US Department of Energy, Office of Basic Energy Sciences, Division of Materials Sciences and Engineering under Award # (DE-FG02-00ER45810), and by the National Science Foundation under Award # (DMR1006713). N.S. gratefully acknowledges support from the IIN Postdoctoral Fellowship and the Northwestern International Institute for Nanotechnology, and from a NIH Ruth L. Kirschstein NRSA postdoctoral fellowship under Award # (1F32NS077728-01A1).
PY - 2013/2
Y1 - 2013/2
N2 - The use of self-assembly for the construction of functional biomaterials is a highly promising and exciting area of research, with great potential for the treatment of injury or disease. By using multiple noncovalent interactions, coded into the molecular design of the constituent components, self-assembly allows for the construction of complex, adaptable, and highly tunable materials with potent biological effects. This review describes some of the seminal advances in the use of self-assembly to make novel systems for regenerative medicine and biology. Materials based on peptides, proteins, DNA, or hybrids thereof have found application in the treatment of a wide range of injuries and diseases, and this review outlines the design principles and practical applications of these systems. Most of the examples covered focus on the synthesis of hydrogels for the scaffolding or transplantation of cells, with an emphasis on the biological, mechanical, and structural properties of the resulting materials. In addition, we will discuss the distinct advantages conferred by self-assembly (compared with traditional covalent materials), and present some of the challenges and opportunities for the next generation of self-assembled biomaterials.
AB - The use of self-assembly for the construction of functional biomaterials is a highly promising and exciting area of research, with great potential for the treatment of injury or disease. By using multiple noncovalent interactions, coded into the molecular design of the constituent components, self-assembly allows for the construction of complex, adaptable, and highly tunable materials with potent biological effects. This review describes some of the seminal advances in the use of self-assembly to make novel systems for regenerative medicine and biology. Materials based on peptides, proteins, DNA, or hybrids thereof have found application in the treatment of a wide range of injuries and diseases, and this review outlines the design principles and practical applications of these systems. Most of the examples covered focus on the synthesis of hydrogels for the scaffolding or transplantation of cells, with an emphasis on the biological, mechanical, and structural properties of the resulting materials. In addition, we will discuss the distinct advantages conferred by self-assembly (compared with traditional covalent materials), and present some of the challenges and opportunities for the next generation of self-assembled biomaterials.
KW - Biomaterials
KW - Peptide amphiphiles
KW - Peptides
KW - Regenerative medicine
KW - Self-assembly
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U2 - 10.1016/j.actamat.2012.10.046
DO - 10.1016/j.actamat.2012.10.046
M3 - Article
AN - SCOPUS:84872744450
SN - 1359-6454
VL - 61
SP - 912
EP - 930
JO - Acta Materialia
JF - Acta Materialia
IS - 3
ER -