Self-assembled signaling aptamer DNA arrays for protein detection

Chenxiang Lin; Evaldas Katilius; Yan Liu; Junping Zhang; Hao Yan

doi:10.1002/anie.200600438

Self-assembled signaling aptamer DNA arrays for protein detection

Chenxiang Lin, Evaldas Katilius, Yan Liu, Junping Zhang, Hao Yan

Research output: Contribution to journal › Article › peer-review

144 Scopus citations

Abstract

(Chemical Equation Presented) Sticking the tiles: A DNA-tile-directed self-assembly of signaling aptamers into high-density nanoarrays allows subnanomolar detection of protein molecules by using confocal fluorescence microscopy imaging. This water-soluble aptamer microarray provides a novel strategy for developing programmable sensor arrays.

Original language	English (US)
Pages (from-to)	5296-5301
Number of pages	6
Journal	Angewandte Chemie - International Edition
Volume	45
Issue number	32
DOIs	https://doi.org/10.1002/anie.200600438
State	Published - Aug 4 2006

Keywords

DNA arrays
Molecular recognition
Protein detection
Self-assembly
Signaling aptamers

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.200600438

Cite this

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title = "Self-assembled signaling aptamer DNA arrays for protein detection",

abstract = "(Chemical Equation Presented) Sticking the tiles: A DNA-tile-directed self-assembly of signaling aptamers into high-density nanoarrays allows subnanomolar detection of protein molecules by using confocal fluorescence microscopy imaging. This water-soluble aptamer microarray provides a novel strategy for developing programmable sensor arrays.",

keywords = "DNA arrays, Molecular recognition, Protein detection, Self-assembly, Signaling aptamers",

author = "Chenxiang Lin and Evaldas Katilius and Yan Liu and Junping Zhang and Hao Yan",

year = "2006",

month = aug,

day = "4",

doi = "10.1002/anie.200600438",

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T1 - Self-assembled signaling aptamer DNA arrays for protein detection

AU - Lin, Chenxiang

AU - Katilius, Evaldas

AU - Liu, Yan

AU - Zhang, Junping

AU - Yan, Hao

PY - 2006/8/4

Y1 - 2006/8/4

N2 - (Chemical Equation Presented) Sticking the tiles: A DNA-tile-directed self-assembly of signaling aptamers into high-density nanoarrays allows subnanomolar detection of protein molecules by using confocal fluorescence microscopy imaging. This water-soluble aptamer microarray provides a novel strategy for developing programmable sensor arrays.

AB - (Chemical Equation Presented) Sticking the tiles: A DNA-tile-directed self-assembly of signaling aptamers into high-density nanoarrays allows subnanomolar detection of protein molecules by using confocal fluorescence microscopy imaging. This water-soluble aptamer microarray provides a novel strategy for developing programmable sensor arrays.

KW - DNA arrays

KW - Molecular recognition

KW - Protein detection

KW - Self-assembly

KW - Signaling aptamers

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M3 - Article

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ER -

Self-assembled signaling aptamer DNA arrays for protein detection

Abstract

Keywords

ASJC Scopus subject areas

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