Secreted immunomodulatory viral proteins as novel biotherapeutics

Alexandra Lucas, Grant McFadden

Research output: Contribution to journalShort surveypeer-review

85 Scopus citations


Many viruses have learned to evade or subvert the host antiviral immune responses by encoding and expressing immunomodulatory proteins that protect the virus from attack by elements of the innate and acquired immune systems. Some of these viral anti-immune regulators are expressed as secreted proteins that engage specific host immune targets in the extracellular environment, where they exhibit potent anti-immune properties. We review here viral immunomodulatory proteins that have been tested as anti-inflammatory reagents in animal models of disease caused by excessive inflammation or hyperactivated immune pathways. The potential for such viral molecules for the development of novel drugs to treat immune-based or inflammatory disorders is discussed.

Original languageEnglish (US)
Pages (from-to)4765-4774
Number of pages10
JournalJournal of Immunology
Issue number8
StatePublished - Oct 15 2004
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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