Scalable dope-coded biosensing particles for protein detection

Nguyen Ly, Nongjian Tao

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


We present a method to fabricate, assemble dope-coded biosensing particles, and demonstrate a scalable high throughput protein detection application. The coded biosensing particles (8 μm in diameter and 280 nm thick) are composed of biosensing/coding/magnetic/adhesive layers and coded via patterned boron doping. Coding via doping is powerful in that it can be easily decoded, permits scalability of bit sizes down to tens of nanometers, generates a large number of codes, and retains uniform particle size and shape independent of particle code for consistent protein analysis. Following suspension phase protein binding, the dope-coded biosensing particles are extracted with an external magnet and analyzed with an atomic force microscope.

Original languageEnglish (US)
Article number043901
Pages (from-to)1-3
Number of pages3
JournalApplied Physics Letters
Issue number4
StatePublished - 2006

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)


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