TY - JOUR
T1 - SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes
AU - HCA Lung Biological Network
AU - Sungnak, Waradon
AU - Huang, Ni
AU - Bécavin, Christophe
AU - Berg, Marijn
AU - Queen, Rachel
AU - Litvinukova, Monika
AU - Talavera-López, Carlos
AU - Maatz, Henrike
AU - Reichart, Daniel
AU - Sampaziotis, Fotios
AU - Worlock, Kaylee B.
AU - Yoshida, Masahiro
AU - Barnes, Josephine L.
AU - Banovich, Nicholas E.
AU - Barbry, Pascal
AU - Brazma, Alvis
AU - Collin, Joseph
AU - Desai, Tushar J.
AU - Duong, Thu Elizabeth
AU - Eickelberg, Oliver
AU - Falk, Christine
AU - Farzan, Michael
AU - Glass, Ian
AU - Gupta, Ravindra K.
AU - Haniffa, Muzlifah
AU - Horvath, Peter
AU - Hubner, Norbert
AU - Hung, Deborah
AU - Kaminski, Naftali
AU - Krasnow, Mark
AU - Kropski, Jonathan A.
AU - Kuhnemund, Malte
AU - Lako, Majlinda
AU - Lee, Haeock
AU - Leroy, Sylvie
AU - Linnarson, Sten
AU - Lundeberg, Joakim
AU - Meyer, Kerstin B.
AU - Miao, Zhichao
AU - Misharin, Alexander V.
AU - Nawijn, Martijn C.
AU - Nikolic, Marko Z.
AU - Noseda, Michela
AU - Ordovas-Montanes, Jose
AU - Oudit, Gavin Y.
AU - Pe’er, Dana
AU - Powell, Joseph
AU - Quake, Steve
AU - Rajagopal, Jay
AU - Shepherd, Douglas
N1 - Publisher Copyright:
© 2020, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2020/5/1
Y1 - 2020/5/1
N2 - We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells’ potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org.
AB - We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells’ potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org.
UR - http://www.scopus.com/inward/record.url?scp=85083969210&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85083969210&partnerID=8YFLogxK
U2 - 10.1038/s41591-020-0868-6
DO - 10.1038/s41591-020-0868-6
M3 - Article
C2 - 32327758
AN - SCOPUS:85083969210
SN - 1078-8956
VL - 26
SP - 681
EP - 687
JO - Nature Medicine
JF - Nature Medicine
IS - 5
ER -