Safe CRISPR: Challenges and Possible Solutions

Michael Pineda; Ashley Lear; James Collins; Samira Kiani

doi:10.1016/j.tibtech.2018.09.010

Safe CRISPR: Challenges and Possible Solutions

Michael Pineda, Ashley Lear, James Collins, Samira Kiani

Research output: Contribution to journal › Review article › peer-review

44 Scopus citations

Abstract

Applications of CRISPR in human health and in gene drives are at the forefront of biological research as tools. This technology will affect humankind and our environment, so as this technology pushes forward, the design and implementation of safety measures is imperative. Novel technologies and forethought in various applications of CRISPR are essential for using this technology safely. Here, we review environmental and health-related safety concerns associated with using CRISPR and ways proposed to minimize risk.

Original language	English (US)
Pages (from-to)	389-401
Number of pages	13
Journal	Trends in Biotechnology
Volume	37
Issue number	4
DOIs	https://doi.org/10.1016/j.tibtech.2018.09.010
State	Published - Apr 2019

Keywords

CRISPR
biosafety
gene drives
gene therapies

ASJC Scopus subject areas

Biotechnology
Bioengineering

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10.1016/j.tibtech.2018.09.010

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abstract = "Applications of CRISPR in human health and in gene drives are at the forefront of biological research as tools. This technology will affect humankind and our environment, so as this technology pushes forward, the design and implementation of safety measures is imperative. Novel technologies and forethought in various applications of CRISPR are essential for using this technology safely. Here, we review environmental and health-related safety concerns associated with using CRISPR and ways proposed to minimize risk.",

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author = "Michael Pineda and Ashley Lear and James Collins and Samira Kiani",

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AU - Collins, James

AU - Kiani, Samira

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AB - Applications of CRISPR in human health and in gene drives are at the forefront of biological research as tools. This technology will affect humankind and our environment, so as this technology pushes forward, the design and implementation of safety measures is imperative. Novel technologies and forethought in various applications of CRISPR are essential for using this technology safely. Here, we review environmental and health-related safety concerns associated with using CRISPR and ways proposed to minimize risk.

KW - CRISPR

KW - biosafety

KW - gene drives

KW - gene therapies

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Safe CRISPR: Challenges and Possible Solutions

Abstract

Keywords

ASJC Scopus subject areas

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