Repeated testing attenuates conditioned place preference with cocaine

M. T. Bardo, J. L. Neisewander, J. S. Miller

Research output: Contribution to journalArticlepeer-review

76 Scopus citations


Cocaine-treated rats acquired a preference for cocaine-associated contextual stimuli (CS) relative to saline-injected control rats. However, when animals were given repeated tests for conditioned place preference intermittent between conditioning trials, they displayed an attenuation in strength of conditioning. This attenuation was not due to pharmacologic tolerance (Experiment 1), but rather reflected a disruption in learning due to exposure to the CS alone (Experiment 2). Like other examples of classical conditioning, the strength of the conditioned response (CR) as assessed by the conditioned place preference model may be influenced by partial reinforcement.

Original languageEnglish (US)
Pages (from-to)239-243
Number of pages5
Issue number2
StatePublished - Jun 1 1986
Externally publishedYes


  • Cocaine
  • Conditioned place preference
  • Drug reinforcement
  • Partial reinforcement

ASJC Scopus subject areas

  • Pharmacology


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