Relationship between depression and pancreatic cancer in the general population

Caroline P. Carney, Laura Jones, Robert F. Woolson, Russell Noyes, Bradley N. Doebbeling

Research output: Contribution to journalArticlepeer-review

60 Scopus citations


Objective: Prior research suggesting a relationship between pancreatic cancer and depression conducted on clinical populations has been subject to recall bias. We reexamined this association using longitudinal population-based data. Methods: This was a retrospective cohort study using longitudinal insurance claims data. Results: Men with mental disorders were more likely to develop pancreatic cancer than those without psychiatric claims (odds ratio 2.4, confidence interval 1.15-4.78). Depression more commonly preceded pancreatic cancer than it did other gastrointestinal malignancies (odds ratio 4.6, confidence interval 1.07-19.4) or all other cancers (odds ratio 4.1, confidence interval 1.05-16.0). Conclusions: Depression and pancreatic cancer are associated in the general population.

Original languageEnglish (US)
Pages (from-to)884-888
Number of pages5
JournalPsychosomatic Medicine
Issue number5
StatePublished - Sep 2003
Externally publishedYes


  • Claims
  • Depression
  • Epidemiology
  • Insurance
  • Mental disorders
  • Pancreatic cancer

ASJC Scopus subject areas

  • Applied Psychology
  • Psychiatry and Mental health


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