Reimagining C(sp3)–N bond formation via a HARC strategy

Michael S. Crocker, Reem Nsouli, Laura K.G. Ackerman-Biegasiewicz

Research output: Contribution to journalArticlepeer-review


Conventional N-alkylation methods have been limited to approaches with high energy barriers and low selectivity. In this issue of Chem, MacMillan and co-workers report an innovative halogen abstraction-radical capture (HARC) strategy via metallaphotoredox catalysis that couples strained and hindered alkyl halides with a diverse range of N-nucleophiles.

Original languageEnglish (US)
Pages (from-to)1688-1691
Number of pages4
Issue number7
StatePublished - Jul 8 2021

ASJC Scopus subject areas

  • General Chemistry
  • Biochemistry
  • Environmental Chemistry
  • General Chemical Engineering
  • Biochemistry, medical
  • Materials Chemistry


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