Regulation of Vi capsular polysaccharide synthesis in Salmonella enterica serotype Typhi.

Javier Santander, Kenneth L. Roland, Roy Curtiss

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


The synthesis of Vi polysaccharide, a major virulence determinant in Salmonella enterica serotype Typhi (S. Typhi), is under the control of two regulatory systems, ompR-envZ and rscB-rscC, which respond to changes in osmolarity. Some S. Typhi isolates exhibit over-expression of Vi polysaccharide, which masks clinical detection of LPS O-antigen. This variation in Vi polysaccharide and O-antigen display (VW variation) has been observed since the initial studies of S. Typhi. We have reported that the status of the rpoS gene is responsible for this phenomenon. We review the regulatory network of the Vi polysaccharide, linking osmolarity and RpoS expression. Also, we discuss how this may impact live attenuated Salmonella vaccine development.

Original languageEnglish (US)
Pages (from-to)412-420
Number of pages9
JournalJournal of infection in developing countries
Issue number6
StatePublished - 2008

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Infectious Diseases
  • Virology


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