Regional neuronal loss in aging and alzheimer’s disease: A brief review

M. Kerry O’Banion, Paul D. Coleman, Linda M. Callahan

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


It is widely recognized that regional neuronal loss occurs during normal aging and that excessive neuronal loss in specific regions is one hallmark of Alzheimer’s disease (AD). Modern counting techniques have started to better define the degree of neuronal loss in aging and AD. Although there is some overlap with regions affected during aging, it is clear that Alzheimer’s disease represents a specific entity. By determining the regions and types of neurons that are vulnerable we can hope to better understand the causes and processes of normal aging and Alzheimer’s disease, as well as develop potential therapies.

Original languageEnglish (US)
Pages (from-to)307-314
Number of pages8
JournalSeminars in the Neurosciences
Issue number5
StatePublished - 1994
Externally publishedYes


  • Amygdala
  • Cerebral cortex
  • Counting methods
  • Hippocampus
  • Subcortical nuclei

ASJC Scopus subject areas

  • General Neuroscience


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