Reduction in added sugar intake and improvement in insulin secretion in overweight Latina adolescents

Jaimie N. Davis, Emily E. Ventura, Gabriel Q. Shaibi, Marc J. Weigensberg, Donna Spruijt-Metz, Richard M. Watanabe, Michael I. Goran

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Background: To date, no study has assessed the effects of modifying carbohydrate intake (specifically decreasing added sugar and increasing fiber) on insulin secretion, nor has any study used an overweight Latino adolescent population. The objective of this study was to examine whether changes in dietary intake, specifically reductions in added sugar and/or increases in fiber, following a 12-week, modified carbohydrate dietary intervention, were associated with changes in insulin secretion and other metabolic risk factors for type 2 diabetes. Methods: Participants were 16 overweight (≥85th percentile BMI) Latina adolescent females (12-17 years) who completed a 12-week modified carbohydrate intervention. Dietary intake was assessed by 3-day diet records, body composition by dual-energy X-ray absorptiometry, and insulin dynamics by an extended 3-hour oral glucose tolerance test (OGTT) at baseline and post-intervention. Results: There was a trend for unadjusted change in reported added sugar intake (% of kcals) to be associated with change in insulin secretion, i.e. IAUC (r = 0.47; p = 0.075), and this relationship became significant after controlling for age, baseline insulin secretion, added sugar and adiposity, and change in adiposity (r = 0.85; p < 0.05). No other changes in dietary variables were related to changes in insulin secretion or other metabolic risk factors for type 2 diabetes. Conclusions: Participants with greater reductions in added sugar intake showed significantly greater improvements in insulin secretion following a modified carbohydrate nutrition intervention. These findings suggest that interventions focused on decreasing added sugar intake have the potential to reduce type 2 diabetes risk in overweight youth.

Original languageEnglish (US)
Pages (from-to)183-193
Number of pages11
JournalMetabolic Syndrome and Related Disorders
Issue number2
StatePublished - Jun 2007
Externally publishedYes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism


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