TY - JOUR
T1 - Reduced incidence of marek’s disease gross lymphomas in t-cell-depleted chickens
AU - Sharma, J. M.
AU - Nazerian, K.
AU - Witter, R. L.
PY - 1977/3
Y1 - 1977/3
N2 - Chickens of line 7, highly susceptible to Marek’s disease (MD), were depleted of T-cells by neonatal thymectomy, total-body g-irradiation, and multiple injections with antithymocyte serum. In two replicate experiments, significantly fewer gross lymphomas were present in T-cell-depleted chickens than in intact or in T-cell-depleted, reconstituted hatchmates; these findings provided evidence that T-cells may be the principal target for MD virus (MDV) transformation. T-cell depletion was not complete, and the presence of microscopic lesions in T-cell-depleted chickens was attributed to residual T-cells. Ten lymphomas from intact chickens and 2 lymphomas from a T-cell-depleted chicken were examined for cellular composition. All lymphomas consisted predominantly of T-cells. The results of this and other published studies indicated that T-cells may have a dual role in MD: They may serve as a target for lymphoma formation by MDV and also may participate in immune surveillance against the disease in resistant chickens.
AB - Chickens of line 7, highly susceptible to Marek’s disease (MD), were depleted of T-cells by neonatal thymectomy, total-body g-irradiation, and multiple injections with antithymocyte serum. In two replicate experiments, significantly fewer gross lymphomas were present in T-cell-depleted chickens than in intact or in T-cell-depleted, reconstituted hatchmates; these findings provided evidence that T-cells may be the principal target for MD virus (MDV) transformation. T-cell depletion was not complete, and the presence of microscopic lesions in T-cell-depleted chickens was attributed to residual T-cells. Ten lymphomas from intact chickens and 2 lymphomas from a T-cell-depleted chicken were examined for cellular composition. All lymphomas consisted predominantly of T-cells. The results of this and other published studies indicated that T-cells may have a dual role in MD: They may serve as a target for lymphoma formation by MDV and also may participate in immune surveillance against the disease in resistant chickens.
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U2 - 10.1093/jnci/58.3.689
DO - 10.1093/jnci/58.3.689
M3 - Article
C2 - 190413
AN - SCOPUS:0017343251
SN - 0027-8874
VL - 58
SP - 689
EP - 692
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
IS - 3
ER -