Reconfigurable DNA origami to generate quasifractal patterns

Fei Zhang, Jeanette Nangreave, Yan Liu, Hao Yan

Research output: Contribution to journalArticlepeer-review

60 Scopus citations


The specificity of Watson-Crick base pairing, unique mechanical properties of DNA, and intrinsic stability of DNA double helices makes DNA an ideal material for the construction of dynamic nanodevices. Rationally designed strand displacement reactions can be used to produce dynamic reconfiguration of DNA nanostructures postassembly. Here we describe a 'fold-release-fold' strategy of multiple strand displacement and hybridization reactions to reconfigure a simple DNA origami structure into a complex, quasifractal pattern, demonstrating a complex transformation of DNA nanoarchitectures.

Original languageEnglish (US)
Pages (from-to)3290-3295
Number of pages6
JournalNano Letters
Issue number6
StatePublished - Jun 13 2012


  • Dynamic DNA nanotechnology
  • fractal
  • reconfiguration
  • strand displacement

ASJC Scopus subject areas

  • Bioengineering
  • General Chemistry
  • General Materials Science
  • Condensed Matter Physics
  • Mechanical Engineering


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