Recombinant Salmonella vectors in vaccine development.

R. Curtiss, S. M. Kelly, S. A. Tinge, C. O. Tacket, M. M. Levine, J. Srinivasan, M. Koopman

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations


A diversity of means are available for the attenuation of Salmonella which can be used to immunize animals and humans orally to elicit mucosal, humoral and cellular immune responses. Avirulent Salmonellae can be genetically engineered to express foreign antigens and the recombinant avirulent Salmonellae are capable of stable, high-level expression of the foreign antigen in the orally immunized animal or human host. The resulting vaccines are safe, efficacious, and are easy and economical to use.

Original languageEnglish (US)
Pages (from-to)23-33
Number of pages11
JournalDevelopments in biological standardization
StatePublished - 1994

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Drug Discovery
  • Public Health, Environmental and Occupational Health


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