Recognition imaging with a DNA aptamer

Liyun Lin, Hongda Wang, Yan Liu, Hao Yan, Stuart Lindsay

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


We have used a DNA-aptamer tethered to an atomic force microscope probe to carry out recognition imaging of IgE molecules attached to a mica substrate. The recognition was efficient (∼90%) and specific, being blocked by injection of IgE molecules in solution, and not being interfered with by high concentrations of a second protein. The signal/noise ratio of the recognition signal was better than that obtained with antibodies, despite the fact that the average force required to break the aptamer-protein bonds was somewhat smaller.

Original languageEnglish (US)
Pages (from-to)4236-4238
Number of pages3
JournalBiophysical journal
Issue number11
StatePublished - Jun 2006

ASJC Scopus subject areas

  • Biophysics


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