Recent advances in electrochemical DNA hybridization sensors

Eli G. Hvastkovs, Daniel Buttry

Research output: Contribution to journalReview articlepeer-review

105 Scopus citations


Even with the advent of industry produced electrochemical DNA analysis chips, electrochemical DNA hybridization detection continues to be an intensive research focus area. The advantages of electrochemical detection continue to inspire efforts to improve selectivity and sensitivity. Here, we summarize the landscape of recent efforts in electrochemical DNA hybridization detection. We specifically focus on some main areas from where novel work continues to originate: redox active molecules designed for specific interaction with double stranded DNA, DNA mimics to eliminate background electrochemical signals, external nanoparticle or enzyme modifications for sensitivity enhancements, split and self-hybridizing single stranded DNA probe modifications, and novel catalytic oxidation techniques. Additionally, we touch on the use of DNA hybridization sensors to monitor alternative biochemical (non-DNA hybridization) processes.

Original languageEnglish (US)
Pages (from-to)1817-1829
Number of pages13
Issue number8
StatePublished - Aug 2010

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Environmental Chemistry
  • Spectroscopy
  • Electrochemistry


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