The equimolar reaction of 3-(2-oxocyclohexyl) propionic acid or 3-(2-oxocyclopentyl) propionic acid and (R)-2-thioxothiazolidine-4-carboxyli ethyl ester (1) with N-methyl-2-chloropyridium salt in the presence of triethylamine produced the corresponding optically active W-3-CZ-oxocycloalkyl) propionyl-2-thioxothiazolidine-4-carboxylic ethyl ester (2.) and N-3-(2-oxocyclopentyl) propionyl-2-thioazolidine-4-carboxylic ethyl ester (2b). When the molar ratio of 3-(2-oxocyclohexyl)-propionic acid to compounds 1 is 2 : 1. 2, and S-excess 3-(2-oxocyclohexyl) propionic acid were obtained. When 2n and 2b react with racemic α-phenylethylamine(molar ratio 1 : 2), the photoactive compound N-3-(2-oxocyclohexyl)propionyl-α-phenylethylaine(Nn) or N-3-(2-oxocyclopentyl)propionyl-a-phenylethylamine(5b) were obtained.
|Original language||English (US)|
|Journal||Kao Teng Hsueh Hsiao Hua Heush Hsueh Pao/ Chemical Journal of Chinese Universities|
|State||Published - Dec 1 1996|
- (R)-2-Thioxothiazolidine-4-carboxylic ethyl ester
- N-3-(2-Oxocycloalkyl)propionyl-2-thioxothiazolidine-4-carboxylic ethyl ester
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