Protein targeting to the yeast vacuole

Joel H. Rothman, Carl T. Yamashiro, Patricia M. Kane, Tom H. Stevens

Research output: Contribution to journalArticlepeer-review

71 Scopus citations


Mutational and gene fusion studies have identified localization signals that target proteins to the yeast lysosome-like vacuole. Genetic analyses have also identified groups of genes (VPS and PEP) whose products are required for recognition of these signals, and sorting and transport of proteins to the vacuole. One of the components involved in protein sorting has been shown to be the vacuolar H+-ATPase, presumably via its role in vacuolar acidification.

Original languageEnglish (US)
Pages (from-to)347-350
Number of pages4
JournalTrends in Biochemical Sciences
Issue number8
StatePublished - Aug 1989

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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