TY - JOUR
T1 - Protein microarrays as tools for functional proteomics
AU - LaBaer, Joshua
AU - Ramachandran, Niroshan
N1 - Funding Information:
We would like to thank Joseph Pearlberg, Eugenie Hainsworth and Joan Davies for their critical reading of this manuscript. JL and NR are supported by NIH/NCI grant R33 CA99191.
PY - 2005/2
Y1 - 2005/2
N2 - Protein microarrays present an innovative and versatile approach to study protein abundance and function at an unprecedented scale. Given the chemical and structural complexity of the proteome, the development of protein microarrays has been challenging. Despite these challenges there has been a marked increase in the use of protein microarrays to map interactions of proteins with various other molecules, and to identify potential disease biomarkers, especially in the area of cancer biology. In this review, we discuss some of the promising advances made in the development and use of protein microarrays.
AB - Protein microarrays present an innovative and versatile approach to study protein abundance and function at an unprecedented scale. Given the chemical and structural complexity of the proteome, the development of protein microarrays has been challenging. Despite these challenges there has been a marked increase in the use of protein microarrays to map interactions of proteins with various other molecules, and to identify potential disease biomarkers, especially in the area of cancer biology. In this review, we discuss some of the promising advances made in the development and use of protein microarrays.
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U2 - 10.1016/j.cbpa.2004.12.006
DO - 10.1016/j.cbpa.2004.12.006
M3 - Review article
C2 - 15701447
AN - SCOPUS:13444280261
SN - 1367-5931
VL - 9
SP - 14
EP - 19
JO - Current Opinion in Chemical Biology
JF - Current Opinion in Chemical Biology
IS - 1
ER -