Prostaglandin E 2 promotes intestinal tumor growth via DNA methylation

Dianren Xia, Dingzhi Wang, Sun Hee Kim, Hiroshi Katoh, Raymond N. Dubois

    Research output: Contribution to journalArticlepeer-review

    141 Scopus citations

    Abstract

    Although aberrant DNA methylation is considered to be one of the key ways by which tumor-suppressor and DNA-repair genes are silenced during tumor initiation and progression, the mechanisms underlying DNA methylation alterations in cancer remain unclear. Here we show that prostaglandin E 2 (PGE 2) silences certain tumor-suppressor and DNA-repair genes through DNA methylation to promote tumor growth. These findings uncover a previously unrecognized role for PGE 2 in the promotion of tumor progression.

    Original languageEnglish (US)
    Pages (from-to)224-226
    Number of pages3
    JournalNature Medicine
    Volume18
    Issue number2
    DOIs
    StatePublished - Feb 2012

    ASJC Scopus subject areas

    • General Biochemistry, Genetics and Molecular Biology

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