TY - GEN
T1 - Promotion of accelerated healing in a mouse wound model with a viral immunomodulator serp-1/chitosan gel
AU - Zhang, Liqiang
AU - Yaron, Jordan R.
AU - Wallace, Sarah
AU - Burgin, Michelle
AU - Tafoya, Amanda
AU - Lucas, Alexandra R.
PY - 2019
Y1 - 2019
N2 - Statement of Purpose: Skin wounds are now considered as one of the major threats to public health and the economy. Based on understanding of the mechanisms of wound healing, numerous therapeutic methods have been developed to promote accelerated wound healing, including slow-release hydrogels for small molecules or growth factors delivery. In this study, we applied the viral immunomodulatory protein Serp-1, a serine proteinase inhibitor (serpin), to promote accelerated wound healing. Serp-1 is a purified, secreted 55kDa glycoprotein derived from Myxomavirus that interferes with the inflammation processes of its host, the European rabbit (Oryctolagus cuniculus) [1]. Our systematic studies on Serp-1 protein demonstrate highly potent anti-inflammatory functions in a wide range of animal models of vascular disease and transplant. Serp-1 also significantly reduced markers of heart damage in a small Phase 2 clinical trial. Serp-1 proved safe in animal models and in Phase I and Phase 2a clinical trials in humans [2]. We examined local delivery of Serp-1 in a hydrogel and assessed wound healing with topical Serp-1 treatment. Topical delivery methods for Serp-1 wound treatments were compared to determine the optimal application approach.
AB - Statement of Purpose: Skin wounds are now considered as one of the major threats to public health and the economy. Based on understanding of the mechanisms of wound healing, numerous therapeutic methods have been developed to promote accelerated wound healing, including slow-release hydrogels for small molecules or growth factors delivery. In this study, we applied the viral immunomodulatory protein Serp-1, a serine proteinase inhibitor (serpin), to promote accelerated wound healing. Serp-1 is a purified, secreted 55kDa glycoprotein derived from Myxomavirus that interferes with the inflammation processes of its host, the European rabbit (Oryctolagus cuniculus) [1]. Our systematic studies on Serp-1 protein demonstrate highly potent anti-inflammatory functions in a wide range of animal models of vascular disease and transplant. Serp-1 also significantly reduced markers of heart damage in a small Phase 2 clinical trial. Serp-1 proved safe in animal models and in Phase I and Phase 2a clinical trials in humans [2]. We examined local delivery of Serp-1 in a hydrogel and assessed wound healing with topical Serp-1 treatment. Topical delivery methods for Serp-1 wound treatments were compared to determine the optimal application approach.
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M3 - Conference contribution
AN - SCOPUS:85065420675
T3 - Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
SP - 508
BT - Society for Biomaterials Annual Meeting and Exposition 2019
PB - Society for Biomaterials
T2 - 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Y2 - 3 April 2019 through 6 April 2019
ER -