TY - JOUR
T1 - Prevalence of dementia and mild cognitive impairment in indigenous Bolivian forager-horticulturalists
AU - Gatz, Margaret
AU - Mack, Wendy J.
AU - Chui, Helena C.
AU - Law, E. Meng
AU - Barisano, Giuseppe
AU - Sutherland, M. Linda
AU - Sutherland, James D.
AU - Eid Rodriguez, Daniel
AU - Quispe Gutierrez, Raul
AU - Copajira Adrian, Juan
AU - Bani Cuata, Jesus
AU - Borenstein, Amy R.
AU - Walters, Ellen E.
AU - Irimia, Andrei
AU - Rowan, Christopher J.
AU - Wann, L. Samuel
AU - Allam, Adel H.
AU - Thompson, Randall C.
AU - Miyamoto, Michael I.
AU - Michalik, David E.
AU - Cummings, Daniel K.
AU - Seabright, Edmond
AU - Garcia, Angela R.
AU - Hooper, Paul L.
AU - Kraft, Thomas S.
AU - Finch, Caleb E.
AU - Thomas, Gregory S.
AU - Stieglitz, Jonathan
AU - Trumble, Benjamin C.
AU - Gurven, Michael D.
AU - Kaplan, Hillard
N1 - Publisher Copyright:
© 2022 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
PY - 2023/1
Y1 - 2023/1
N2 - Introduction: We evaluated the prevalence of dementia and mild cognitive impairment (MCI) in indigenous Tsimane and Moseten, who lead a subsistence lifestyle. Methods: Participants from population-based samples ≥ 60 years of age (n = 623) were assessed using adapted versions of the Modified Mini-Mental State Examination, informant interview, longitudinal cognitive testing and brain computed tomography (CT) scans. Results: Tsimane exhibited five cases of dementia (among n = 435; crude prevalence = 1.2%, 95% confidence interval [CI]: 0.4, 2.7); Moseten exhibited one case (among n = 169; crude prevalence = 0.6%, 95% CI: 0.0, 3.2), all age ≥ 80 years. Age-standardized MCI prevalence was 7.7% (95% CI: 5.2, 10.3) in Tsimane and 9.8% (95% CI: 4.9, 14.6) in Moseten. Cognitive impairment was associated with visuospatial impairments, parkinsonian symptoms, and vascular calcification in the basal ganglia. Discussion: The prevalence of dementia in this cohort is among the lowest in the world. Widespread intracranial medial arterial calcifications suggest a previously unrecognized, non-Alzheimer's disease (AD) dementia phenotype.
AB - Introduction: We evaluated the prevalence of dementia and mild cognitive impairment (MCI) in indigenous Tsimane and Moseten, who lead a subsistence lifestyle. Methods: Participants from population-based samples ≥ 60 years of age (n = 623) were assessed using adapted versions of the Modified Mini-Mental State Examination, informant interview, longitudinal cognitive testing and brain computed tomography (CT) scans. Results: Tsimane exhibited five cases of dementia (among n = 435; crude prevalence = 1.2%, 95% confidence interval [CI]: 0.4, 2.7); Moseten exhibited one case (among n = 169; crude prevalence = 0.6%, 95% CI: 0.0, 3.2), all age ≥ 80 years. Age-standardized MCI prevalence was 7.7% (95% CI: 5.2, 10.3) in Tsimane and 9.8% (95% CI: 4.9, 14.6) in Moseten. Cognitive impairment was associated with visuospatial impairments, parkinsonian symptoms, and vascular calcification in the basal ganglia. Discussion: The prevalence of dementia in this cohort is among the lowest in the world. Widespread intracranial medial arterial calcifications suggest a previously unrecognized, non-Alzheimer's disease (AD) dementia phenotype.
KW - Moseten
KW - Tsimane
KW - cognitive dysfunction
KW - dementia
KW - mental status and dementia tests
UR - http://www.scopus.com/inward/record.url?scp=85126000223&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85126000223&partnerID=8YFLogxK
U2 - 10.1002/alz.12626
DO - 10.1002/alz.12626
M3 - Article
C2 - 35262289
AN - SCOPUS:85126000223
SN - 1552-5260
VL - 19
SP - 44
EP - 55
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
IS - 1
ER -