Pressure effects on collective density fluctuations in water and protein solutions

Daniela Russo, Alessio Laloni, Alessandra Filabozzi, Matthias Heyden

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Neutron Brillouin scattering and molecular dynamics simulations have been used to investigate protein hydration water density fluctuations as a function of pressure. Our results show significant differences between the pressure and density dependence of collective dynamics in bulk water and in concentrated protein solutions. Pressure-induced changes in the tetrahedral order of the water HB network have direct consequences for the high-frequency sound velocity and damping coefficients, which we find to be a sensitive probe for changes in the HB network structure as well as the wetting of biomolecular surfaces.

Original languageEnglish (US)
Pages (from-to)11410-11415
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number43
StatePublished - Oct 24 2017
Externally publishedYes


  • Collective THz modes
  • High pressure
  • Hydration water
  • Molecular dynamics
  • Neutron scattering

ASJC Scopus subject areas

  • General


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