Prediction of near-term risk of developing breast cancer using computerized features from bilateral mammograms

Wenqing Sun, Bin Zheng, Fleming Lure, Teresa Wu, Jianying Zhang, Benjamin Y. Wang, Edward C. Saltzstein, Wei Qian

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Asymmetry of bilateral mammographic tissue density and patterns is a potentially strong indicator of having or developing breast abnormalities or early cancers. The purpose of this study is to design and test the global asymmetry features from bilateral mammograms to predict the near-term risk of women developing detectable high risk breast lesions or cancer in the next sequential screening mammography examination. The image dataset includes mammograms acquired from 90 women who underwent routine screening examinations, all interpreted as negative and not recalled by the radiologists during the original screening procedures. A computerized breast cancer risk analysis scheme using four image processing modules, including image preprocessing, suspicious region segmentation, image feature extraction, and classification was designed to detect and compute image feature asymmetry between the left and right breasts imaged on the mammograms. The highest computed area under curve (AUC) is 0.754 ± 0.024 when applying the new computerized aided diagnosis (CAD) scheme to our testing dataset. The positive predictive value and the negative predictive value were 0.58 and 0.80, respectively.

Original languageEnglish (US)
Pages (from-to)348-357
Number of pages10
JournalComputerized Medical Imaging and Graphics
Issue number5
StatePublished - Jul 2014


  • Bilateral mammographic asymmetry feature
  • Breast cancer
  • Computerized breast cancer risk analysis
  • Mammogram
  • Near-term breast cancer risk assessment

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Computer Vision and Pattern Recognition
  • Health Informatics
  • Computer Graphics and Computer-Aided Design


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