Abstract
Despite much attention to the use of biomarkers for predicting Alzheimer disease, little information is available at the individual level. We used the population-based Mayo Clinic Study of Aging to estimate absolute risk of cognitive impairment by biomarker group. Risk increased with age and any biomarker abnormality. For example, a 75-year-old with abnormal amyloid and cortical thinning biomarkers has about a 20% chance of cognitive impairment by age 80 years, whereas with normal biomarkers the chance is <10%. Persons with only one abnormal biomarker had similar intermediate risks. ANN NEUROL 2019;85:155–160.
Original language | English (US) |
---|---|
Pages (from-to) | 155-160 |
Number of pages | 6 |
Journal | Annals of Neurology |
Volume | 85 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2019 |
Externally published | Yes |
ASJC Scopus subject areas
- Neurology
- Clinical Neurology