Poly(oxyethylene) based surface coatings for poly(dimethylsiloxane) microchannels

Wibke Hellmich, Jan Regtmeier, Thanh Tu Duong, Robert Ros, Dario Anselmetti, Alexandra Ros

Research output: Contribution to journalArticlepeer-review

113 Scopus citations


Control of surface properties in microfluidic systems is an indispensable prerequisite for successful bioanalytical applications. Poly(dimethylsiloxane) (PDMS) microfluidic devices are hampered from unwanted adsorption of biomolecules and lack of methods to control electroosmotic flow (EOF). In this paper, we propose different strategies to coat PDMS surfaces with poly(oxyethylene) (POE) molecules of varying chain lengths. The native PDMS surface is pretreated by exposure to UV irradiation or to an oxygen plasma, and the covalent linkage of POE-silanes as well as physical adsorption of a triblock-copolymer (F108) are studied. Contact angle measurements and atomic force microscopy (AFM) imaging revealed homogeneous attachment of POE-silanes and F108 to the PDMS surfaces. In the case of F108, different adsorption mechanisms to hydrophilic and hydrophobic PDMS are discussed. Determination of the electroosmotic mobilities of these coatings in PDMS microchannels prove their use for electrokinetic applications in which EOF reduction is inevitable and protein adsorption has to be suppressed.

Original languageEnglish (US)
Pages (from-to)7551-7557
Number of pages7
Issue number16
StatePublished - Aug 2 2005
Externally publishedYes

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry


Dive into the research topics of 'Poly(oxyethylene) based surface coatings for poly(dimethylsiloxane) microchannels'. Together they form a unique fingerprint.

Cite this