TY - JOUR
T1 - Polygenic risk, family cohesion, and adolescent aggression in Mexican American and European American families
T2 - Developmental pathways to alcohol use
AU - Elam, Kit
AU - Chassin, Laurie
AU - Pandika, Danielle
N1 - Funding Information:
Causadias José M. Cicchetti Dante Editors Elam Kit K. Chassin Laurie Pandika Danielle Arizona State University This research was supported by National Institute of Alcohol Abuse and Alcoholism Grants AA016213 and AA022097 (to L.C.) and the National Institute on Drug Abuse and National Institutes of Health: Office of the Director, and Office of Behavioral and Social Sciences Research Grant K01DA042828 (to K.K.E). Address correspondence and reprint requests to: Kit K. Elam, Assistant Professor, T. Denny Sanford School for Social and Family Dynamics , Arizona State University , 951 S. Cady Mall, Tempe, AZ 85287 ; E-mail: kit.elam@asu.edu . 31 08 2018 12 2018 30 5
Publisher Copyright:
© Copyright Cambridge University Press 2018.
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Poor family cohesion and elevated adolescent aggression are associated with greater alcohol use in adolescence and early adulthood. In addition, evocative gene-environment correlations (rGEs) can underlie the interplay between offspring characteristics and negative family functioning, contributing to substance use. Gene-environment interplay has rarely been examined in racial/ethnic minority populations. The current study examined adolescents' polygenic risk scores for aggression in evocative rGEs underlying aggression and family cohesion during adolescence, their contributions to alcohol use in early adulthood (n = 479), and differences between Mexican American and European American subsamples. Results suggest an evocative rGE between polygenic risk scores, aggression, and low family cohesion, with aggression contributing to low family cohesion over time. Greater family cohesion was associated with lower levels of alcohol use in early adulthood and this association was stronger for Mexican American adolescents compared to European American adolescents. Results are discussed with respect to integration of culture and racial/ethnic minority samples into genetic research and implications for alcohol use.
AB - Poor family cohesion and elevated adolescent aggression are associated with greater alcohol use in adolescence and early adulthood. In addition, evocative gene-environment correlations (rGEs) can underlie the interplay between offspring characteristics and negative family functioning, contributing to substance use. Gene-environment interplay has rarely been examined in racial/ethnic minority populations. The current study examined adolescents' polygenic risk scores for aggression in evocative rGEs underlying aggression and family cohesion during adolescence, their contributions to alcohol use in early adulthood (n = 479), and differences between Mexican American and European American subsamples. Results suggest an evocative rGE between polygenic risk scores, aggression, and low family cohesion, with aggression contributing to low family cohesion over time. Greater family cohesion was associated with lower levels of alcohol use in early adulthood and this association was stronger for Mexican American adolescents compared to European American adolescents. Results are discussed with respect to integration of culture and racial/ethnic minority samples into genetic research and implications for alcohol use.
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U2 - 10.1017/S0954579418000901
DO - 10.1017/S0954579418000901
M3 - Article
C2 - 30168407
AN - SCOPUS:85052925589
SN - 0954-5794
VL - 30
SP - 1715
EP - 1728
JO - Development and psychopathology
JF - Development and psychopathology
IS - 5
ER -