Plasmonic-Based Electrochemical Impedance Imaging of Electrical Activities in Single Cells

Xian Wei Liu, Yunze Yang, Wei Wang, Shaopeng Wang, Ming Gao, Jie Wu, Nongjian Tao

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


Studying electrical activities in cells, such as action potential and its propagation in neurons, requires a sensitive and non-invasive analytical tool that can image local electrical signals with high spatial and temporal resolutions. Here we report a plasmonic-based electrochemical impedance imaging technique to study transient electrical activities in single cells. The technique is based on the conversion of the electrical signal into a plasmonic signal, which is imaged optically without labels. We demonstrate imaging of the fast initiation and propagation of action potential within single neurons, and validate the imaging technique with the traditional patch clamp technique. We anticipate that the plasmonic imaging technique will contribute to the study of electrical activities in various cellular processes.

Original languageEnglish (US)
Pages (from-to)8855-8859
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number30
StatePublished - Jul 17 2017


  • electrical activity
  • electroanalytical chemistry
  • electrochemical impedance microscopy
  • single cells
  • surface plasmon resonances

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)


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