Physical bioenergetics: Energy fluxes, budgets, and constraints in cells

Xingbo Yang; Matthias Heinemann; Jonathon Howard; Greg Huber; Srividya Iyer-Biswas; Guillaume Le Treut; Michael Lynch; Kristi L. Montooth; Daniel J. Needleman; Simone Pigolotti; Jonathan Rodenfels; Pierre Ronceray; Sadasivan Shankar; Iman Tavassoly; Shashi Thutupalli; Denis V. Titov; Jin Wang; Peter J. Foster

doi:10.1073/pnas.2026786118

Physical bioenergetics: Energy fluxes, budgets, and constraints in cells

Xingbo Yang, Matthias Heinemann, Jonathon Howard, Greg Huber, Srividya Iyer-Biswas, Guillaume Le Treut, Michael Lynch, Kristi L. Montooth, Daniel J. Needleman, Simone Pigolotti, Jonathan Rodenfels, Pierre Ronceray, Sadasivan Shankar, Iman Tavassoly, Shashi Thutupalli, Denis V. Titov, Jin Wang, Peter J. Foster

Life Sciences, School of (SOLS)

Research output: Contribution to journal › Review article › peer-review

39 Scopus citations

Abstract

Cells are the basic units of all living matter which harness the flow of energy to drive the processes of life. While the biochemical networks involved in energy transduction are well-characterized, the energetic costs and constraints for specific cellular processes remain largely unknown. In particular, what are the energy budgets of cells? What are the constraints and limits energy flows impose on cellular processes? Do cells operate near these limits, and if so how do energetic constraints impact cellular functions? Physics has provided many tools to study nonequilibrium systems and to define physical limits, but applying these tools to cell biology remains a challenge. Physical bioenergetics, which resides at the interface of nonequilibrium physics, energy metabolism, and cell biology, seeks to understand how much energy cells are using, how they partition this energy between different cellular processes, and the associated energetic constraints. Here we review recent advances and discuss open questions and challenges in physical bioenergetics.

Original language	English (US)
Article number	e2026786118
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	118
Issue number	26
DOIs	https://doi.org/10.1073/pnas.2026786118
State	Published - Jun 29 2021

Keywords

Energetic constraints
Energetic costs
Energy fluxes
Physical bioenergetics

ASJC Scopus subject areas

General

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10.1073/pnas.2026786118

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Yang, X., Heinemann, M., Howard, J., Huber, G., Iyer-Biswas, S., Le Treut, G., Lynch, M., Montooth, K. L., Needleman, D. J., Pigolotti, S., Rodenfels, J., Ronceray, P., Shankar, S., Tavassoly, I., Thutupalli, S., Titov, D. V., Wang, J., & Foster, P. J. (2021). Physical bioenergetics: Energy fluxes, budgets, and constraints in cells. Proceedings of the National Academy of Sciences of the United States of America, 118(26), Article e2026786118. https://doi.org/10.1073/pnas.2026786118

Yang, X, Heinemann, M, Howard, J, Huber, G, Iyer-Biswas, S, Le Treut, G, Lynch, M, Montooth, KL, Needleman, DJ, Pigolotti, S, Rodenfels, J, Ronceray, P, Shankar, S, Tavassoly, I, Thutupalli, S, Titov, DV, Wang, J & Foster, PJ 2021, 'Physical bioenergetics: Energy fluxes, budgets, and constraints in cells', Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 26, e2026786118. https://doi.org/10.1073/pnas.2026786118

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AU - Rodenfels, Jonathan

AU - Ronceray, Pierre

AU - Shankar, Sadasivan

AU - Tavassoly, Iman

AU - Thutupalli, Shashi

AU - Titov, Denis V.

AU - Wang, Jin

AU - Foster, Peter J.

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AB - Cells are the basic units of all living matter which harness the flow of energy to drive the processes of life. While the biochemical networks involved in energy transduction are well-characterized, the energetic costs and constraints for specific cellular processes remain largely unknown. In particular, what are the energy budgets of cells? What are the constraints and limits energy flows impose on cellular processes? Do cells operate near these limits, and if so how do energetic constraints impact cellular functions? Physics has provided many tools to study nonequilibrium systems and to define physical limits, but applying these tools to cell biology remains a challenge. Physical bioenergetics, which resides at the interface of nonequilibrium physics, energy metabolism, and cell biology, seeks to understand how much energy cells are using, how they partition this energy between different cellular processes, and the associated energetic constraints. Here we review recent advances and discuss open questions and challenges in physical bioenergetics.

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Physical bioenergetics: Energy fluxes, budgets, and constraints in cells

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Keywords

ASJC Scopus subject areas

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