TY - JOUR
T1 - Physical Activity and Trajectory of Cognitive Change in Older Persons
T2 - Mayo Clinic Study of Aging
AU - Krell-Roesch, Janina
AU - Syrjanen, Jeremy A.
AU - Bezold, Jelena
AU - Trautwein, Sandra
AU - Barisch-Fritz, Bettina
AU - Boes, Klaus
AU - Woll, Alexander
AU - Forzani, Erica
AU - Kremers, Walter K.
AU - MacHulda, Mary M.
AU - Mielke, Michelle M.
AU - Knopman, David S.
AU - Petersen, Ronald C.
AU - Vassilaki, Maria
AU - Geda, Yonas E.
N1 - Publisher Copyright:
© 2024 IOS Press. All rights reserved.
PY - 2024
Y1 - 2024
N2 - Background: Little is known about the association between physical activity (PA) and cognitive trajectories in older adults. Objective: To examine the association between PA and change in memory, language, attention, visuospatial skills, and global cognition, and a potential impact of sex or Apolipoprotein E (APOE) ϵ4 status. Methods: Longitudinal study derived from the population-based Mayo Clinic Study of Aging, including 2,060 cognitively unimpaired males and females aged ≥70 years. Engagement in midlife (ages 50-65) and late-life (last year) PA was assessed using a questionnaire. Neuropsychological testing was done every 15 months (mean follow-up 5.8 years). We ran linear mixed-effect models to examine whether mid- or late-life PA at three intensities (mild, moderate, vigorous) was associated with cognitive z-scores. Results: Light intensity midlife PA was associated with less decline in memory function compared to the no-PA reference group (time x light PA; estimate [standard error] 0.047 [0.016], p = 0.004). Vigorous late-life PA was associated with less decline in language (0.033 [0.015], p = 0.030), attention (0.032 [0.017], p = 0.050), and global cognition (0.039 [0.016], p = 0.012). Females who were physically inactive in midlife experienced more pronounced cognitive decline than females physically active in midlife and males regardless of PA (p-values for time interaction terms with midlife PA levels and sex were all p < 0.05 for global cognition). APOE ϵ4 carriership did not moderate the association between PA and cognition. Conclusion: Engaging in PA, particularly of vigorous intensity in late-life, was associated with less pronounced decline in global and domain-specific cognition. This association may differ by sex.
AB - Background: Little is known about the association between physical activity (PA) and cognitive trajectories in older adults. Objective: To examine the association between PA and change in memory, language, attention, visuospatial skills, and global cognition, and a potential impact of sex or Apolipoprotein E (APOE) ϵ4 status. Methods: Longitudinal study derived from the population-based Mayo Clinic Study of Aging, including 2,060 cognitively unimpaired males and females aged ≥70 years. Engagement in midlife (ages 50-65) and late-life (last year) PA was assessed using a questionnaire. Neuropsychological testing was done every 15 months (mean follow-up 5.8 years). We ran linear mixed-effect models to examine whether mid- or late-life PA at three intensities (mild, moderate, vigorous) was associated with cognitive z-scores. Results: Light intensity midlife PA was associated with less decline in memory function compared to the no-PA reference group (time x light PA; estimate [standard error] 0.047 [0.016], p = 0.004). Vigorous late-life PA was associated with less decline in language (0.033 [0.015], p = 0.030), attention (0.032 [0.017], p = 0.050), and global cognition (0.039 [0.016], p = 0.012). Females who were physically inactive in midlife experienced more pronounced cognitive decline than females physically active in midlife and males regardless of PA (p-values for time interaction terms with midlife PA levels and sex were all p < 0.05 for global cognition). APOE ϵ4 carriership did not moderate the association between PA and cognition. Conclusion: Engaging in PA, particularly of vigorous intensity in late-life, was associated with less pronounced decline in global and domain-specific cognition. This association may differ by sex.
KW - Cognitive trajectories
KW - community-dwelling persons
KW - late-life
KW - midlife
KW - physical activity
UR - http://www.scopus.com/inward/record.url?scp=85185249571&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85185249571&partnerID=8YFLogxK
U2 - 10.3233/AIAD230003
DO - 10.3233/AIAD230003
M3 - Article
AN - SCOPUS:85185249571
SN - 2210-5727
VL - 10
SP - 3
EP - 14
JO - Advances in Alzheimer's Disease
JF - Advances in Alzheimer's Disease
ER -