Phylogenetic and preliminary phenotypic analysis of yeast PAQR receptors: Potential antifungal targets

Nancy Y. Villa, Patricia Moussatche, Stephen G. Chamberlin, Anuj Kumar, Thomas J. Lyons

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Proteins belonging to the Progestin and AdipoQ Receptor (PAQR) superfamily of membrane bound receptors are ubiquitously found in fungi. Nearly, all fungi possess two evolutionarily distinct paralogs of PAQR protein, which we have called the PQRA and PQRB subtypes. In the model fungus Saccharomyces cerevisiae, these subtypes are represented by the Izh2p and Izh3p proteins, respectively. S. cerevisiae also possesses two additional PQRA-type receptors called Izh1p and Izh4p that are restricted to other species within the "Saccharomyces complex". Izh2p has been the subject of several recent investigations and is of particular interest because it regulates fungal growth in response to proteins produced by plants and, as such, represents a new paradigm for interspecies communication. We demonstrate that IZH2 and IZH3 gene dosage affects resistance to polyene antifungal drugs. Moreover, we provide additional evidence that Izh2p and Izh3p negatively regulate fungal filamentation. These data suggest that agonists of these receptors might make antifungal therapeutics, either by inhibiting fungal development or by sensitizing fungi to the toxic effects of current antifungal therapies. This is particularly relevant for pathogenic fungi such as Candida glabrata that are closely related to S. cerevisiae and contain the same complement of PAQR receptors.

Original languageEnglish (US)
Pages (from-to)134-152
Number of pages19
JournalJournal of Molecular Evolution
Issue number3-4
StatePublished - Oct 2011
Externally publishedYes


  • Adiponectin
  • Antifungal
  • Filamentation
  • Fungi
  • Osmotin
  • PAQR
  • Phylogeny
  • Polyene
  • Progesterone
  • Saccharomyces cerevisiae

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics


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