Perspective: A program to improve protein biomarker discovery for cancer

Ruedi Aebersold; Leigh Anderson; Richard Caprioli; Brian Druker; Leland Hartwell; Richard Smith

doi:10.1021/pr050027n

Perspective: A program to improve protein biomarker discovery for cancer

Ruedi Aebersold, Leigh Anderson, Richard Caprioli, Brian Druker, Leland Hartwell, Richard Smith

Research output: Contribution to journal › Review article › peer-review

131 Scopus citations

Abstract

Biomarkers for cancer risk, early detection, prognosis, and therapeutic response promise to revolutionize cancer management. Protein biomarkers offer tremendous potential in this regard due to their great diversity and intimate involvement in physiology. An effective program to discover protein biomarkers using existing technology will require team science, an integrated informatics platform, identification and quantitation of candidate biomarkers in disease tissue, mouse models of disease, standardized reagents for analyzing candidate biomarkers in bodily fluids, and implementation of automation. Technology improvements for better fractionation of the proteome, selection of specific biomarkers from complex mixtures, and multiplexed assay of biomarkers would greatly enhance progress.

Original language	English (US)
Pages (from-to)	1104-1109
Number of pages	6
Journal	Journal of Proteome Research
Volume	4
Issue number	4
DOIs	https://doi.org/10.1021/pr050027n
State	Published - Jul 2005
Externally published	Yes

Keywords

Biomarker
Cancer
Discovery
Informatics
Reagents
Research platform

ASJC Scopus subject areas

Biochemistry
Chemistry(all)

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10.1021/pr050027n

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abstract = "Biomarkers for cancer risk, early detection, prognosis, and therapeutic response promise to revolutionize cancer management. Protein biomarkers offer tremendous potential in this regard due to their great diversity and intimate involvement in physiology. An effective program to discover protein biomarkers using existing technology will require team science, an integrated informatics platform, identification and quantitation of candidate biomarkers in disease tissue, mouse models of disease, standardized reagents for analyzing candidate biomarkers in bodily fluids, and implementation of automation. Technology improvements for better fractionation of the proteome, selection of specific biomarkers from complex mixtures, and multiplexed assay of biomarkers would greatly enhance progress.",

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AU - Aebersold, Ruedi

AU - Anderson, Leigh

AU - Caprioli, Richard

AU - Druker, Brian

AU - Hartwell, Leland

AU - Smith, Richard

PY - 2005/7

Y1 - 2005/7

N2 - Biomarkers for cancer risk, early detection, prognosis, and therapeutic response promise to revolutionize cancer management. Protein biomarkers offer tremendous potential in this regard due to their great diversity and intimate involvement in physiology. An effective program to discover protein biomarkers using existing technology will require team science, an integrated informatics platform, identification and quantitation of candidate biomarkers in disease tissue, mouse models of disease, standardized reagents for analyzing candidate biomarkers in bodily fluids, and implementation of automation. Technology improvements for better fractionation of the proteome, selection of specific biomarkers from complex mixtures, and multiplexed assay of biomarkers would greatly enhance progress.

AB - Biomarkers for cancer risk, early detection, prognosis, and therapeutic response promise to revolutionize cancer management. Protein biomarkers offer tremendous potential in this regard due to their great diversity and intimate involvement in physiology. An effective program to discover protein biomarkers using existing technology will require team science, an integrated informatics platform, identification and quantitation of candidate biomarkers in disease tissue, mouse models of disease, standardized reagents for analyzing candidate biomarkers in bodily fluids, and implementation of automation. Technology improvements for better fractionation of the proteome, selection of specific biomarkers from complex mixtures, and multiplexed assay of biomarkers would greatly enhance progress.

KW - Biomarker

KW - Cancer

KW - Discovery

KW - Informatics

KW - Reagents

KW - Research platform

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Perspective: A program to improve protein biomarker discovery for cancer

Abstract

Keywords

ASJC Scopus subject areas

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