Pathophysiology, Associations, and Consequences of Circadian Rhythm Sleep Disorder

S. K. Crowley, S. D. Youngstedt

Research output: Chapter in Book/Report/Conference proceedingChapter


Circadian rhythm sleep disorders (CRSDs) are a family of sleep disorders that result from a mismatch between the body's endogenous clock and the 24-h environmental and sleep-wake schedule. CRSDs are associated with significant psychological, physiological, and social consequences, ranging from minor social impact to serious medical conditions such as cardiovascular disease and neurological disorder. The degree to which a CRSD affects the individual depends greatly on the level of malsynchronization of the circadian system with requirements and schedules of daily living. This article discusses the pathophysiology, associations, and consequences of the six major CRSDs currently recognized in the International Classification of Sleep Disorders.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Sleep
PublisherElsevier Inc.
Number of pages6
ISBN (Electronic)9780123786111
ISBN (Print)9780123786104
StatePublished - Jan 1 2013
Externally publishedYes


  • Advanced sleep phase disorder
  • Chronotype
  • Circadian rhythm
  • Circadian rhythm sleep disorder
  • Delayed sleep phase disorder
  • Free-running disorder
  • Irregular sleep-wake disorder
  • Jet lag disorder
  • Light exposure
  • Melatonin
  • Shift work disorder

ASJC Scopus subject areas

  • Medicine (miscellaneous)


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