Pathogenesis and management of pruritus in cholestatic liver disease

Mohamad H. Imam, Andrea A. Gossard, Emmanouil Sinakos, Keith D. Lindor

Research output: Contribution to journalReview articlepeer-review

42 Scopus citations


Patients with cholestatic liver diseases such as primary biliary cirrhosis, primary sclerosing cholangitis and intrahepatic cholestasis of pregnancy commonly complain of pruritus. The underlying pathogenesis remains obscure with several mediators possibly playing an important role; these include lysophosphatidic acid, bile salts, opioids, histamine and progesterone metabolites. We describe in this review novel insights into the pathogenesis and management of pruritus in patients with cholestasis.

Original languageEnglish (US)
Pages (from-to)1150-1158
Number of pages9
JournalJournal of Gastroenterology and Hepatology (Australia)
Issue number7
StatePublished - Jul 2012


  • Cholestatic
  • Itch
  • Liver
  • Pruritus

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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