Parallel adaptation of rabbit populations to myxoma virus

Joel M. Alves; Miguel Carneiro; Jade Y. Cheng; Ana Lemos de Matos; Masmudur Rahman; Liisa Loog; Paula F. Campos; Nathan Wales; Anders Eriksson; Andrea Manica; Tanja Strive; Stephen C. Graham; Sandra Afonso; Diana J. Bell; Laura Belmont; Jonathan P. Day; Susan J. Fuller; Stéphane Marchandeau; William J. Palmer; Guillaume Queney; Alison K. Surridge; Filipe G. Vieira; Douglas McFadden; Rasmus Nielsen; M. Thomas; P. Gilbert; Pedro J. Esteves; Nuno Ferrand; Francis M. Jiggins

doi:10.1126/science.aau7285

Parallel adaptation of rabbit populations to myxoma virus

Joel M. Alves, Miguel Carneiro, Jade Y. Cheng, Ana Lemos de Matos, Masmudur Rahman, Liisa Loog, Paula F. Campos, Nathan Wales, Anders Eriksson, Andrea Manica, Tanja Strive, Stephen C. Graham, Sandra Afonso, Diana J. Bell, Laura Belmont, Jonathan P. Day, Susan J. Fuller, Stéphane Marchandeau, William J. Palmer, Guillaume QueneyAlison K. Surridge, Filipe G. Vieira, Douglas McFadden, Rasmus Nielsen, M. Thomas, P. Gilbert, Pedro J. Esteves, Nuno Ferrand, Francis M. Jiggins

Research output: Contribution to journal › Article › peer-review

103 Scopus citations

Abstract

In the 1950s the myxoma virus was released into European rabbit populations in Australia and Europe, decimating populations and resulting in the rapid evolution of resistance. We investigated the genetic basis of resistance by comparing the exomes of rabbits collected before and after the pandemic. We found a strong pattern of parallel evolution, with selection on standing genetic variation favoring the same alleles in Australia, France, and the United Kingdom. Many of these changes occurred in immunity-related genes, supporting a polygenic basis of resistance. We experimentally validated the role of several genes in viral replication and showed that selection acting on an interferon protein has increased the protein’s antiviral effect.

Original language	English (US)
Pages (from-to)	1319-1326
Number of pages	8
Journal	Science
Volume	363
Issue number	6433
DOIs	https://doi.org/10.1126/science.aau7285
State	Published - Mar 22 2019

ASJC Scopus subject areas

General

Access to Document

10.1126/science.aau7285

Cite this

Alves, J. M., Carneiro, M., Cheng, J. Y., de Matos, A. L., Rahman, M., Loog, L., Campos, P. F., Wales, N., Eriksson, A., Manica, A., Strive, T., Graham, S. C., Afonso, S., Bell, D. J., Belmont, L., Day, J. P., Fuller, S. J., Marchandeau, S., Palmer, W. J., ... Jiggins, F. M. (2019). Parallel adaptation of rabbit populations to myxoma virus. Science, 363(6433), 1319-1326. https://doi.org/10.1126/science.aau7285

Alves, JM, Carneiro, M, Cheng, JY, de Matos, AL, Rahman, M, Loog, L, Campos, PF, Wales, N, Eriksson, A, Manica, A, Strive, T, Graham, SC, Afonso, S, Bell, DJ, Belmont, L, Day, JP, Fuller, SJ, Marchandeau, S, Palmer, WJ, Queney, G, Surridge, AK, Vieira, FG, McFadden, D, Nielsen, R, Thomas, M, Gilbert, P, Esteves, PJ, Ferrand, N & Jiggins, FM 2019, 'Parallel adaptation of rabbit populations to myxoma virus', Science, vol. 363, no. 6433, pp. 1319-1326. https://doi.org/10.1126/science.aau7285

@article{80ebeaf7053a46999d46ab0e36a7838a,

title = "Parallel adaptation of rabbit populations to myxoma virus",

abstract = "In the 1950s the myxoma virus was released into European rabbit populations in Australia and Europe, decimating populations and resulting in the rapid evolution of resistance. We investigated the genetic basis of resistance by comparing the exomes of rabbits collected before and after the pandemic. We found a strong pattern of parallel evolution, with selection on standing genetic variation favoring the same alleles in Australia, France, and the United Kingdom. Many of these changes occurred in immunity-related genes, supporting a polygenic basis of resistance. We experimentally validated the role of several genes in viral replication and showed that selection acting on an interferon protein has increased the protein{\textquoteright}s antiviral effect.",

author = "Alves, {Joel M.} and Miguel Carneiro and Cheng, {Jade Y.} and {de Matos}, {Ana Lemos} and Masmudur Rahman and Liisa Loog and Campos, {Paula F.} and Nathan Wales and Anders Eriksson and Andrea Manica and Tanja Strive and Graham, {Stephen C.} and Sandra Afonso and Bell, {Diana J.} and Laura Belmont and Day, {Jonathan P.} and Fuller, {Susan J.} and St{\'e}phane Marchandeau and Palmer, {William J.} and Guillaume Queney and Surridge, {Alison K.} and Vieira, {Filipe G.} and Douglas McFadden and Rasmus Nielsen and M. Thomas and P. Gilbert and Esteves, {Pedro J.} and Nuno Ferrand and Jiggins, {Francis M.}",

note = "Publisher Copyright: {\textcopyright} 2017 The Authors.",

year = "2019",

month = mar,

day = "22",

doi = "10.1126/science.aau7285",

language = "English (US)",

volume = "363",

pages = "1319--1326",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "6433",

}

TY - JOUR

T1 - Parallel adaptation of rabbit populations to myxoma virus

AU - Alves, Joel M.

AU - Carneiro, Miguel

AU - Cheng, Jade Y.

AU - de Matos, Ana Lemos

AU - Rahman, Masmudur

AU - Loog, Liisa

AU - Campos, Paula F.

AU - Wales, Nathan

AU - Eriksson, Anders

AU - Manica, Andrea

AU - Strive, Tanja

AU - Graham, Stephen C.

AU - Afonso, Sandra

AU - Bell, Diana J.

AU - Belmont, Laura

AU - Day, Jonathan P.

AU - Fuller, Susan J.

AU - Marchandeau, Stéphane

AU - Palmer, William J.

AU - Queney, Guillaume

AU - Surridge, Alison K.

AU - Vieira, Filipe G.

AU - McFadden, Douglas

AU - Nielsen, Rasmus

AU - Thomas, M.

AU - Gilbert, P.

AU - Esteves, Pedro J.

AU - Ferrand, Nuno

AU - Jiggins, Francis M.

PY - 2019/3/22

Y1 - 2019/3/22

N2 - In the 1950s the myxoma virus was released into European rabbit populations in Australia and Europe, decimating populations and resulting in the rapid evolution of resistance. We investigated the genetic basis of resistance by comparing the exomes of rabbits collected before and after the pandemic. We found a strong pattern of parallel evolution, with selection on standing genetic variation favoring the same alleles in Australia, France, and the United Kingdom. Many of these changes occurred in immunity-related genes, supporting a polygenic basis of resistance. We experimentally validated the role of several genes in viral replication and showed that selection acting on an interferon protein has increased the protein’s antiviral effect.

AB - In the 1950s the myxoma virus was released into European rabbit populations in Australia and Europe, decimating populations and resulting in the rapid evolution of resistance. We investigated the genetic basis of resistance by comparing the exomes of rabbits collected before and after the pandemic. We found a strong pattern of parallel evolution, with selection on standing genetic variation favoring the same alleles in Australia, France, and the United Kingdom. Many of these changes occurred in immunity-related genes, supporting a polygenic basis of resistance. We experimentally validated the role of several genes in viral replication and showed that selection acting on an interferon protein has increased the protein’s antiviral effect.

UR - http://www.scopus.com/inward/record.url?scp=85061759943&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85061759943&partnerID=8YFLogxK

U2 - 10.1126/science.aau7285

DO - 10.1126/science.aau7285

M3 - Article

C2 - 30765607

AN - SCOPUS:85061759943

SN - 0036-8075

VL - 363

SP - 1319

EP - 1326

JO - Science

JF - Science

IS - 6433

ER -

Parallel adaptation of rabbit populations to myxoma virus

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this