Pairwise linkage analysis of 11 loci on human chromosome 4

J. C. Murray, K. H. Buetow, M. Smith, L. Carlock, A. Chakravarti, R. F. Ferrell, L. Gedamu, C. Gilliam, R. Shiang, C. R. DeHaven

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


New RFLPs are described for INP10 and interleukin 2. The 55 pairwise genetic linkage relationships for these two loci and nine additional loci on the long arm of chromosome 4 (4q) are reported. Fifteen new linkage are established, and new data are added to the four previously reported linkages on 4q. Tight linkage of interleukin 2 (T-cell growth factor), epidermal growth factor, and alcohol dehydrogenase is described. Significant differences were observed between male and female recombination rates. The female rate was estimated to be 1.27 times the male rate. On the basis of these pairwise results, the order for the 11 loci is D4S35-GC-(ALB/AFP)-MT2P1-D4S1-INP10-ADH3-(EGF/IL2)-(FBB/FBA/FBG)-MNS. This preliminary order can serve as a starting point for more detailed multipoint analysis.

Original languageEnglish (US)
Pages (from-to)490-497
Number of pages8
JournalAmerican Journal of Human Genetics
Issue number3
StatePublished - Jan 1 1988
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)


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