Pairwise linkage analysis of 11 loci on human chromosome 4

J. C. Murray; K. H. Buetow; M. Smith; L. Carlock; A. Chakravarti; R. F. Ferrell; L. Gedamu; C. Gilliam; R. Shiang; C. R. DeHaven

Pairwise linkage analysis of 11 loci on human chromosome 4

J. C. Murray, K. H. Buetow, M. Smith, L. Carlock, A. Chakravarti, R. F. Ferrell, L. Gedamu, C. Gilliam, R. Shiang, C. R. DeHaven

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23 Scopus citations

Abstract

New RFLPs are described for INP10 and interleukin 2. The 55 pairwise genetic linkage relationships for these two loci and nine additional loci on the long arm of chromosome 4 (4q) are reported. Fifteen new linkage are established, and new data are added to the four previously reported linkages on 4q. Tight linkage of interleukin 2 (T-cell growth factor), epidermal growth factor, and alcohol dehydrogenase is described. Significant differences were observed between male and female recombination rates. The female rate was estimated to be 1.27 times the male rate. On the basis of these pairwise results, the order for the 11 loci is D4S35-GC-(ALB/AFP)-MT2P1-D4S1-INP10-ADH3-(EGF/IL2)-(FBB/FBA/FBG)-MNS. This preliminary order can serve as a starting point for more detailed multipoint analysis.

Original language	English (US)
Pages (from-to)	490-497
Number of pages	8
Journal	American Journal of Human Genetics
Volume	42
Issue number	3
State	Published - Jan 1 1988
Externally published	Yes

ASJC Scopus subject areas

Genetics
Genetics(clinical)

Cite this

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title = "Pairwise linkage analysis of 11 loci on human chromosome 4",

abstract = "New RFLPs are described for INP10 and interleukin 2. The 55 pairwise genetic linkage relationships for these two loci and nine additional loci on the long arm of chromosome 4 (4q) are reported. Fifteen new linkage are established, and new data are added to the four previously reported linkages on 4q. Tight linkage of interleukin 2 (T-cell growth factor), epidermal growth factor, and alcohol dehydrogenase is described. Significant differences were observed between male and female recombination rates. The female rate was estimated to be 1.27 times the male rate. On the basis of these pairwise results, the order for the 11 loci is D4S35-GC-(ALB/AFP)-MT2P1-D4S1-INP10-ADH3-(EGF/IL2)-(FBB/FBA/FBG)-MNS. This preliminary order can serve as a starting point for more detailed multipoint analysis.",

author = "Murray, {J. C.} and Buetow, {K. H.} and M. Smith and L. Carlock and A. Chakravarti and Ferrell, {R. F.} and L. Gedamu and C. Gilliam and R. Shiang and DeHaven, {C. R.}",

year = "1988",

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language = "English (US)",

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pages = "490--497",

journal = "American Journal of Human Genetics",

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T1 - Pairwise linkage analysis of 11 loci on human chromosome 4

AU - Murray, J. C.

AU - Buetow, K. H.

AU - Smith, M.

AU - Carlock, L.

AU - Chakravarti, A.

AU - Ferrell, R. F.

AU - Gedamu, L.

AU - Gilliam, C.

AU - Shiang, R.

AU - DeHaven, C. R.

PY - 1988/1/1

Y1 - 1988/1/1

N2 - New RFLPs are described for INP10 and interleukin 2. The 55 pairwise genetic linkage relationships for these two loci and nine additional loci on the long arm of chromosome 4 (4q) are reported. Fifteen new linkage are established, and new data are added to the four previously reported linkages on 4q. Tight linkage of interleukin 2 (T-cell growth factor), epidermal growth factor, and alcohol dehydrogenase is described. Significant differences were observed between male and female recombination rates. The female rate was estimated to be 1.27 times the male rate. On the basis of these pairwise results, the order for the 11 loci is D4S35-GC-(ALB/AFP)-MT2P1-D4S1-INP10-ADH3-(EGF/IL2)-(FBB/FBA/FBG)-MNS. This preliminary order can serve as a starting point for more detailed multipoint analysis.

AB - New RFLPs are described for INP10 and interleukin 2. The 55 pairwise genetic linkage relationships for these two loci and nine additional loci on the long arm of chromosome 4 (4q) are reported. Fifteen new linkage are established, and new data are added to the four previously reported linkages on 4q. Tight linkage of interleukin 2 (T-cell growth factor), epidermal growth factor, and alcohol dehydrogenase is described. Significant differences were observed between male and female recombination rates. The female rate was estimated to be 1.27 times the male rate. On the basis of these pairwise results, the order for the 11 loci is D4S35-GC-(ALB/AFP)-MT2P1-D4S1-INP10-ADH3-(EGF/IL2)-(FBB/FBA/FBG)-MNS. This preliminary order can serve as a starting point for more detailed multipoint analysis.

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AN - SCOPUS:0023921837

SN - 0002-9297

VL - 42

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JO - American Journal of Human Genetics

JF - American Journal of Human Genetics

IS - 3

ER -

Pairwise linkage analysis of 11 loci on human chromosome 4

Abstract

ASJC Scopus subject areas

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