Oxygen supply limits the heat tolerance of lizard embryos

Colton Smith, Rory S. Telemeco, Michael Angilletta, John M. VandenBrooks

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


The mechanisms that set the thermal limits to life remain uncertain. Classically, researchers thought that heating kills by disrupting the structures of proteins or membranes, but an alternative hypothesis focuses on the demand for oxygen relative to its supply. We evaluated this alternative hypothesis by comparing the lethal temperature for lizard embryos developing at oxygen concentrations of 10-30%. Embryos exposed to normoxia and hyperoxia survived to higher temperatures than those exposed to hypoxia, suggesting that oxygen limitation sets the thermal maximum. As all animals pass through an embryonic stage where respiratory and cardiovascular systemsmust develop, oxygen limitation may limit the thermal niches of terrestrial animals as well as aquatic ones.

Original languageEnglish (US)
Article number20150113
JournalBiology letters
Issue number4
StatePublished - Apr 1 2015


  • Critical thermal maximum
  • Oxygen-limited thermal tolerance
  • Sceloporus tristichus
  • Temperature

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Agricultural and Biological Sciences(all)


Dive into the research topics of 'Oxygen supply limits the heat tolerance of lizard embryos'. Together they form a unique fingerprint.

Cite this